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  • By the River Piedra I Sat Down and Wept: A Novel of Forgiveness

    By Paulo Coelho

    Our Price: $14.99
    • Format: Paperback
    • ISBN-13: 9780061122095
    • Publisher: Harper Perennial
    • Published: June 2006
    From the author of the international bestseller The Alchemist, comes a poignant, richly poetic story that reflects the depth of love an dlife. Rarely does adolescent love reach its full potential, but what happens when two young lovers reunite after eleven years? Now they are together once again, embarking on a journey fraught with difficulties, as long-buried demons of blame and resentment resurface after more than a decade. 180p.
  • Targeting the Wnt Pathway in Cancer

    By Kathleen H. Goss

    Our Price: $249.00
    • Format: Hardcover
    • ISBN-13: 9781441980229
    • Publisher: Springer Verlag
    • Published: January 2011
    The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathogenesis in multiple in vitro and in vivo models systems, suggesting that the pathway represents an attractive therapeutic target. Recent efforts have focused on innovative strategies to antagonize Wnt signaling at various levels of the pathway - from attenuating the extracellular signaling through the Wnt receptors to modulating the catenin destruction complex to blocking catenin-mediated transcription. Many of these approaches have been largely successful in preclinical validation studies and have been met with considerable enthusiasm to move forward into clinical trials. In this book, we highlight the recent advances in our understanding of the complexity of the Wnt pathway, particularly its intricate regulation and cross-talk with other key signal transduction pathways in normal and tumor cells. As a way to comprehend the role of Wnt pathway activation in tumor initiation and progression, we discuss the importance of Wnt signaling in embryonic and tissue development and stem cell maintenance and self-renewal. The evidence for aberrant Wnt pathway activation in human solid and hematopoietic cancers, as well as a few of the genetic mouse models that mimic the Wnt pathway deregulation observed in some of these tumor types, is reviewed. Lastly, we summarize the current status of the development of Wnt pathway inhibitors, their efficacy in preclinical models and their potential as therapeutic agents for cancer. It is an exciting time in the Wnt signaling field - one that represents a key crossroad between dissecting the molecular details of the pathway and translating that work into promising targeted tumor therapies - that is likely to profoundly impact this research area for years to come.
  • The Alchemist

    By Paulo Coelho

    Our Price: $7.50
    • Format: Paperback
    • ISBN-13: 9780062502186
    • Publisher: Harper SanFrancisco
    • Published: 1998
    The magical story of Santiago, an Andalusian shepherd boy who travels in search of a worldly treasure...and a fateful encounter with the alchemist. 177p.
  • The Alchemist (25th Anniversary Edition)

    By Paulo Coelho

    Our Price: $15.29
    • Format: Paperback
    • ISBN-13: 9780062315007
    • Publisher: HarperOne
    • Published: April 2014
    A special 25th anniversary edition of Paulo Coehlo's extraordinary international bestselling phenomenon—the inspiring spiritual tale of self-discovery that has touched millions of lives around the world.Combing magic, mysticism, wisdom and wonder, The Alchemist has become a modern classic, selling millions of copies around the world and transforming the lives of countless readers across generations.Paulo Coelho's masterpiece tells the mystical story of Santiago, an Andalusian shepherd boy who yearns to travel in search of a worldly treasure. His quest will lead him to riches far different—and far more satisfying—than he ever imagined. Santiago's journey teaches us about the essential wisdom of listening to our hearts, of recognizing opportunity and learning to read the omens strewn along life's path, and, most importantly, to follow our dreams.
  • The Pilgrimage

    By Paulo Coelho

    Our Price: $15.99
    • Format: Paperback
    • ISBN-13: 9780061687457
    • Publisher: HarperCollins
    • Published: September 2008
    Step inside this captivating account of Paulo Coelho's pilgrimage along the road to Santiago. This fascinating parable explores the need to find one's own path. In the end, we discover that the extraordinary is always found in the ordinary and simple ways of everyday people. Part adventure story, part guide to self-discovery, this compelling tale delivers the perfect combination of enchantment and insight. 274p.
  • The Valkyries: An Encounter With Angels

    By Paulo Coelho

    Our Price: $15.99
    • Format: Paperback
    • ISBN-13: 9780062513342
    • Publisher: Perennial
    • Published: 1998
    Forty-day quest into the Mojave Desert produces encounter an with strange warrior women who travel on motorcycles. A true-life odyssey. 212p.

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